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BEGIN:VCALENDAR VERSION:2.0 METHOD:PUBLISH CALSCALE:GREGORIAN PRODID:-//WordPress - MECv6.5.5//EN X-ORIGINAL-URL:https://oursymposium.sites.unlv.edu/ X-WR-CALNAME:Office of Undergraduate Research (OUR) Fall 2021 Virtual Undergraduate Research Symposium X-WR-CALDESC: REFRESH-INTERVAL;VALUE=DURATION:PT1H X-PUBLISHED-TTL:PT1H X-MS-OLK-FORCEINSPECTOROPEN:TRUE BEGIN:VEVENT CLASS:PUBLIC DTSTART;TZID=UTC:20211115T000000 DTEND;TZID=UTC:20211120T000000 DTSTAMP:20211026T000000 UID:MEC-46f76a4bda9a9579eab38a8f6eabcda1@oursymposium.sites.unlv.edu CREATED:20211026 LAST-MODIFIED:20211110 PRIORITY:5 TRANSP:OPAQUE SUMMARY:HNSE-P5-1. Behavioral Evaluation of a Novel Mouse Model With the Loss of GABAB Receptors DESCRIPTION:\nhttps://www.youtube.com/watch?v=6epJ9omauUQ ( https://www.youtube.com/watch?v=6epJ9omauUQ )\n\nSkylyn J. Ferguson1\nAmanda M. Leisgang Osse2\nAndrew A. Ortiz2\nChloe Mamales2\nWill Poston1\nFaculty Mentor: Jefferson Kinney, Ph.D.1\n1College of Sciences, School of Life Sciences\n2College of Liberal Arts, Department of Psychology\n3School of Integrated Health Sciences, Department of Brain Health\nABSTRACT\nNeurodegenerative diseases (NDD) are described as the progressive degeneration of the central and peripheral nervous system’s structures and functions. Neuroinflammation may contribute to deficits in memory and cognition and has shown to be a hallmark in many NDD including: Parkinson’s Disease, Alzheimer’s Disease, and amyotrophic lateral sclerosis (ALS). Microglia are the main glial cells responsible for mediating neuroinflammation. Microglia alterations could be a key in the chronic neuroinflammation observed in NDD. In addition to neuroinflammation, alterations in neurotransmitter systems can contribute to deficits in learning and memory. The principal inhibitory neurotransmitter in the brain, gamma aminobutyric acid (GABA), has demonstrated to be essential for cognition. Changes in the GABAergic system could lead to impairment of learning and memory. GABAB receptors are G-protein-coupled receptors found on microglia exhibiting anti-inflammatory properties. To investigate the role of the GABAB receptors in neuroinflammation, we developed a novel mouse model, GAB/CX3ert, with a knockdown of the GABAB receptor on microglia. In this study, we examined the learning and memory of the GAB/CXert mice compared to wildtype controls, as well as comparing males and females.\n URL:https://oursymposium.sites.unlv.edu/program/behavioral-evaluation-of-a-novel-mouse-model-with-the-loss-of-gabab-receptors/ ORGANIZER;CN=The Office of Undergraduate Research:MAILTO:our@unlv.edu CATEGORIES:Arts, Humanities, and Social Sciences END:VEVENT END:VCALENDAR