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BEGIN:VCALENDAR VERSION:2.0 METHOD:PUBLISH CALSCALE:GREGORIAN PRODID:-//WordPress - MECv6.5.5//EN X-ORIGINAL-URL:https://oursymposium.sites.unlv.edu/ X-WR-CALNAME:Office of Undergraduate Research (OUR) Fall 2021 Virtual Undergraduate Research Symposium X-WR-CALDESC: REFRESH-INTERVAL;VALUE=DURATION:PT1H X-PUBLISHED-TTL:PT1H X-MS-OLK-FORCEINSPECTOROPEN:TRUE BEGIN:VEVENT CLASS:PUBLIC DTSTART;TZID=UTC:20211115T000000 DTEND;TZID=UTC:20211120T000000 DTSTAMP:20211028T000000 UID:MEC-3812f9a59b634c2a9c574610eaba5bed@oursymposium.sites.unlv.edu CREATED:20211028 LAST-MODIFIED:20211110 PRIORITY:5 TRANSP:OPAQUE SUMMARY:HNSE-O2-1. Characterization of Neuronal Protein-protein Interactions using Baits from the 15q11.2 Locus DESCRIPTION:\n\nNatnael Basazinew1\nNabih Ghani1\nChing Lan (Lanie) Chang2\nRichard Gu3\nHayley Baker1\nMoonis Ghani1\nVan Vo, Ph.D.2\nFaculty Mentor: Edwin Oh, Ph.D.2\n1College of Sciences, Department of Life Sciences\n2College of Sciences, Nevada Institute of Personalized Medicine\n3College of Sciences, Department of Chemistry and Biochemistry\nABSTRACT\nThe 15q11.2 microdeletion syndrome results in neurodevelopmental deficits that include developmental delay and psychiatric conditions. While comprehensive microarray studies have demonstrated that four genes (NIPA1, NIPA2, CYFIP1, and TUBGCP5) within the 15q11.2 locus are associated with behavioral and anatomical pathology, a unifying hypothesis to correlate gene function to phenotype has not been established. Copy number variations within chromosome 15 are relatively frequent in approximately 1% of the population. An increasing number of genes are associated with intellectual disability (ID) and autism spectrum disorders (ASDs). Fragile X mental retardation gene 1 (FMR1), whose silencing causes the Fragile X syndrome, is the most common form of ID and autism. The precise functional significance of the CYFIP/FMRP interaction is not understood fully; however, among the interactors of FMRP, CYFIP1/2 are good candidates for ID and autism, based on their genetic implication and functional properties. CYFIP1 and CYFIP2 represent a link between Rac1, the WAVE complex, and FMRP, favoring the cross-talk between actin polymerization and translational control. Thus, the role of Cyfip1 in brain connectivity is yet to be explored. Using mass spectrometry, immunoblotting, and immunoprecipitation datasets, we will characterize protein-protein interactions and mechanisms associated with the manifestation of neural disorders linked with the 15q11.2 microdeletion syndrome, and more specifically, with CYFIP1 copy number variation.\n URL:https://oursymposium.sites.unlv.edu/program/characterization-of-neuronal-protein-protein-interactions-using-baits-from-the-15q11-2-locus/ ORGANIZER;CN=The Office of Undergraduate Research:MAILTO:our@unlv.edu CATEGORIES:Health & Natural Sciences & Engineering END:VEVENT END:VCALENDAR