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BEGIN:VCALENDAR VERSION:2.0 METHOD:PUBLISH CALSCALE:GREGORIAN PRODID:-//WordPress - MECv6.5.5//EN X-ORIGINAL-URL:https://oursymposium.sites.unlv.edu/ X-WR-CALNAME:Office of Undergraduate Research (OUR) Fall 2021 Virtual Undergraduate Research Symposium X-WR-CALDESC: REFRESH-INTERVAL;VALUE=DURATION:PT1H X-PUBLISHED-TTL:PT1H X-MS-OLK-FORCEINSPECTOROPEN:TRUE BEGIN:VEVENT CLASS:PUBLIC DTSTART;TZID=UTC:20211115T000000 DTEND;TZID=UTC:20211120T000000 DTSTAMP:20211028T000000 UID:MEC-1397386b7a1507535c59764a15ee0c98@oursymposium.sites.unlv.edu CREATED:20211028 LAST-MODIFIED:20211110 PRIORITY:5 TRANSP:OPAQUE SUMMARY:HNSE-O2-6. Interrogating a Centrosomal-specific Role for DDX3X During Brain Development DESCRIPTION:\n\nNabih Ghani1\nNatnael Basazinew1\nChing Lan (Lanie) Chang2\nRichard Gu3\nHayley Baker1\nVan Vo, Ph.D.2\nFaculty Mentor: Edwin Oh, Ph.D.2\n1College of Sciences, Department of Life Sciences\n2College of Sciences, Nevada Institute of Personalized Medicine\n3College of Sciences, Department of Chemistry and Biochemistry\nABSTRACT\nDEAD-box proteins are RNA helicases that are characterized by a conserved Asp-Glu-Ala-Asp motif. These proteins are involved in a variety of processes within cells, ranging from cell cycle progression to the innate immune response. DDX3X is a protein-coding gene found on the X chromosome that codes for a DEAD-box RNA helicase and variants in this gene are believed to be involved in 1-3% of unexplained intellectual disabilities in females. The DDX3X protein is vital for cell viability and is found in all tissues within the body. While mutations in the human DDX3X gene have been characterized to cause intellectual disabilities, seizures, and autism, the mechanism that associates the genetic lesions to pathology is still under investigation. Here, we use mass spectrometry to characterize a complex interactome of DDX3X in the mouse brain. We also verify the novel interactions using immunoblotting techniques and show that phenotypes associated with loss of function DDX3X mutations can be explained through some centrosomal proteins identified in our screen. The data suggest that the loss of DDX3X from the centrosome can perturb neuronal development.\n URL:https://oursymposium.sites.unlv.edu/program/interrogating-a-centrosomal-specific-role-for-ddx3x-during-brain-development/ ORGANIZER;CN=The Office of Undergraduate Research:MAILTO:our@unlv.edu CATEGORIES:Health & Natural Sciences & Engineering END:VEVENT END:VCALENDAR