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BEGIN:VCALENDAR VERSION:2.0 METHOD:PUBLISH CALSCALE:GREGORIAN PRODID:-//WordPress - MECv6.5.5//EN X-ORIGINAL-URL:https://oursymposium.sites.unlv.edu/ X-WR-CALNAME:Office of Undergraduate Research (OUR) Fall 2021 Virtual Undergraduate Research Symposium X-WR-CALDESC: REFRESH-INTERVAL;VALUE=DURATION:PT1H X-PUBLISHED-TTL:PT1H X-MS-OLK-FORCEINSPECTOROPEN:TRUE BEGIN:VEVENT CLASS:PUBLIC DTSTART;TZID=UTC:20211115T000000 DTEND;TZID=UTC:20211120T000000 DTSTAMP:20211110T000000 UID:MEC-1c67df9e0a5cfefa030b853983324004@oursymposium.sites.unlv.edu CREATED:20211110 LAST-MODIFIED:20211115 PRIORITY:5 TRANSP:OPAQUE SUMMARY:HNSE-O3-5. Development of Novel Synthetic Methods of Lysine-Specific Demethylase 1(LSD1) Inhibitors as Anti-Cancer Reagents DESCRIPTION:\n\nCitlally Lopez Flores1\nLilian Huynh2\nJeffrey Ash2\nFaculty Mentor: Jun Yong Kang, Ph.D.1\n1College of Sciences, Department of Life Sciences\n2College of Sciences, Department of Chemistry and Biochemistry\nABSTRACT\nCancer is the malignant growth and division of abnormal cells. The proliferation of cancerous cells is harmful to the human body since it interferes with many biological processes. Lysine-specific demethylase 1(LSD1) protein levels are expressed at high levels in many types of cancers such as teratocarcinoma, embryonic carcinoma, and embryonic stem cells. Gene expression in cancerous cells can be repressed by lysine-methylation on histones which ensures the maintenance of a tightly organized histone. Targeting LSD1 protein levels can significantly impair the growth of cancer due to the methylated histones being unable to participate in gene expression. Lysine-specific demethylase 1(LSD1) inhibitors prevent the proliferation of cancer by targeting the high concentrations of lysine-specific demethylases vital for cell proliferation. CBB3001 is a LSD1 inhibitor which has been able to inhibit the growth of cancer, warranting further investigation. The aim of this research project is to synthesize CBB3001 by developing efficient synthetic methods and to then create a CBB3001 derivatization library. The researchers involved will synthesize CBB3001, a LSD1 inhibitor, by developing several synthetic pathways with variability along specific steps to produce CBB3001 derivatives. CBB3001, and its derivatives, show great promise in functioning as anti-cancer reagents for many types of human cancers.\n URL:https://oursymposium.sites.unlv.edu/program/development-of-novel-synthetic-methods-of-lysine-specific-demethylase-1lsd1-inhibitors-as-anti-cancer-reagents/ ORGANIZER;CN=The Office of Undergraduate Research:MAILTO:our@unlv.edu CATEGORIES:Health & Natural Sciences & Engineering END:VEVENT END:VCALENDAR