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BEGIN:VCALENDAR VERSION:2.0 METHOD:PUBLISH CALSCALE:GREGORIAN PRODID:-//WordPress - MECv6.5.5//EN X-ORIGINAL-URL:https://oursymposium.sites.unlv.edu/ X-WR-CALNAME:Office of Undergraduate Research (OUR) Fall 2021 Virtual Undergraduate Research Symposium X-WR-CALDESC: REFRESH-INTERVAL;VALUE=DURATION:PT1H X-PUBLISHED-TTL:PT1H X-MS-OLK-FORCEINSPECTOROPEN:TRUE BEGIN:VEVENT CLASS:PUBLIC DTSTART;TZID=UTC:20211115T000000 DTEND;TZID=UTC:20211120T000000 DTSTAMP:20211111T000000 UID:MEC-8b313cbf30999888de32da1ec83ff503@oursymposium.sites.unlv.edu CREATED:20211111 LAST-MODIFIED:20211111 PRIORITY:5 TRANSP:OPAQUE SUMMARY:HNSE-P6-6. Synthesis of Novel Fluorescent Probes for the Early Diagnosis of Alzheimer’s Disease DESCRIPTION:\n\n\nMatthew Le1\nPradip Bhowmik, Ph.D.2\nDavid King2\nFaculty Mentor: Haesook Han, Ph.D.2\n1College of Sciences, Department of Life Sciences\n2College of Sciences, Department of Chemistry and Biochemistry\nABSTRACT\nAlzheimer’s Disease (AD) is a pervasive form of dementia that accounts for 60% to 70% of progressive cognitive impairment within the elderly population. This neurodegenerative disease manifests itself through a progressive decline in motor function, memory, and cognition. AD is closely associated with the accumulation of amyloid- β (Aβ) proteins that form insoluble plaques. The formation of Aβ is a hallmark of AD and can serve as a means for diagnosis. Our objective was to synthesize potential molecular probes for a practical and safe means to detecting AD in its early stages. We synthesized the target fluorescent probes by Knoevenagel condensation to yield p-styryl pyridinium salts of different carbon chain lengths by reacting terephthalaldehyde and γ-picolinium bromide salts. Additionally, counterion exchanges of bromide to tosylate and triflimide were subsequently carried out for each salt in the series. The synthesized probes were characterized by proton (1H) and carbon 13 (13C) nuclear magnetic resonance spectra analysis, elemental analysis, differential scanning calorimetry, thermogravimetric analysis, and fluorescence spectroscopy. Their fluorescent properties suggest that the synthesized probes are viable candidates to be tested in vivo for their binding to insoluble plaques. These findings will serve as a foundation for research into further carbon chain extensions, counter ion exchanges, and structural modifications of fluorescent probes.\n URL:https://oursymposium.sites.unlv.edu/program/synthesis-of-novel-fluorescent-probes-for-the-early-diagnosis-of-alzheimers-disease/ ORGANIZER;CN=The Office of Undergraduate Research:MAILTO:our@unlv.edu CATEGORIES:Health & Natural Sciences & Engineering END:VEVENT END:VCALENDAR