HNSE-P5-1. Behavioral Evaluation of a Novel Mouse Model With the Loss of GABAB Receptors
Skylyn J. Ferguson1
Amanda M. Leisgang Osse2
Andrew A. Ortiz2
Chloe Mamales2
Will Poston1
Faculty Mentor: Jefferson Kinney, Ph.D.1
1College of Sciences, School of Life Sciences
2College of Liberal Arts, Department of Psychology
3School of Integrated Health Sciences, Department of Brain Health
ABSTRACT
Neurodegenerative diseases (NDD) are described as the progressive degeneration of the central and peripheral nervous system’s structures and functions. Neuroinflammation may contribute to deficits in memory and cognition and has shown to be a hallmark in many NDD including: Parkinson’s Disease, Alzheimer’s Disease, and amyotrophic lateral sclerosis (ALS). Microglia are the main glial cells responsible for mediating neuroinflammation. Microglia alterations could be a key in the chronic neuroinflammation observed in NDD. In addition to neuroinflammation, alterations in neurotransmitter systems can contribute to deficits in learning and memory. The principal inhibitory neurotransmitter in the brain, gamma aminobutyric acid (GABA), has demonstrated to be essential for cognition. Changes in the GABAergic system could lead to impairment of learning and memory. GABAB receptors are G-protein-coupled receptors found on microglia exhibiting anti-inflammatory properties. To investigate the role of the GABAB receptors in neuroinflammation, we developed a novel mouse model, GAB/CX3ert, with a knockdown of the GABAB receptor on microglia. In this study, we examined the learning and memory of the GAB/CXert mice compared to wildtype controls, as well as comparing males and females.
Date
- Nov 15 - 19 2021
- Expired!
Time
- All Day
Labels
- HNSE: Poster Session 5
Organizer
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The Office of Undergraduate Research
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Phone
702-895-4771 -
Email
our@unlv.edu -
Website
http://unlv.edu/our
Speakers
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Amanda M. Leisgange Osse | College of Liberal Arts
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Andrew A. Ortiz | College of Liberal Arts
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Dr. Jefferson Kinney | School of Integrated Health Sciences
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Skylyn J. Ferguson | College of Sciences
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Will Poston | College of Sciences
Hello and welcome to my presentation! I appreciate you taking the time to listen, and I welcome you to ask any questions or share any comments you might have in the comments.