HNSE-O2-3. Development of a Novel Alzheimer’s Therapy: Reduction of Inflammation
Aurora Emini1
Lorena Samentar, Ph.D.1
Faculty Mentor: Nora Caberoy, Ph.D.1
1College of Sciences, Department of Life Sciences
ABSTRACT
Alzheimer’s disease is a progressive neurodegenerative disease affecting about 5.8M Americans and nearly 48M people worldwide. Currently, there is no cure for Alzheimer’s. Available treatments only address the cognitive and behavioral symptoms but do not delay or stop the progression of the disease. One characteristic of Alzheimer’s is the deposition of amyloid beta plaques in the brain. Clearance of these plaques involves receptors on the cell surface whose activation results to the release of harmful inflammatory factors. This leads to the eventual death of nerve cells. At the Caberoy Lab, we develop a novel Alzheimer’s therapy through amyloid beta clearance without causing inflammation by using the hybrid protein that we have engineered. We have previously demonstrated that our hybrid facilitated amyloid beta clearance. So our main question here is, can our hybrid reduce inflammation in Alzheimer’s disease? We observe a significant reduction in levels of harmful oxidative and inflammatory factors in the presence of our hybrid compared to the control. This implies that our hybrid does not only facilitate clearance of plaques but also reduce inflammation. Our promising result is very exciting as we join the race in developing a cure for Alzheimer’s disease.
Date
- Nov 15 - 19 2021
- Expired!
Time
- All Day
Labels
- HNSE: Podium Session 2
Organizer
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The Office of Undergraduate Research
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Phone
702-895-4771 -
Email
our@unlv.edu -
Website
http://unlv.edu/our
Speakers
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Aurora Emini | College of Sciences
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Dr. Lorena Samentar | College of Sciences
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Dr. Nora Caberoy | College of Sciences
Hi Aurora!
First I would like to say you did a wonderful job explaining such a complex topic. Alzheimer’s disease is a very scary disease that effects many of our elderly here in the United States. I’m not a bio major by any means, but your explanation about how the hybrid facilitates Amyloid cells was very easy to grasp with your use of visuals and data. You provided evidence and explained the how! Great job.
Hi everyone! I will be presenting on the development of a novel Alzheimer’s therapy with a focus on the reduction of inflammation. I would appreciate any questions or feedback through the comment section below. Thank you for listening!