HNSE-O3-5. Development of Novel Synthetic Methods of Lysine-Specific Demethylase 1(LSD1) Inhibitors as Anti-Cancer Reagents

Citlally Lopez Flores1
Lilian Huynh2
Jeffrey Ash2
Faculty Mentor: Jun Yong Kang, Ph.D.1
1College of Sciences, Department of Life Sciences
2College of Sciences, Department of Chemistry and Biochemistry

Cancer is the malignant growth and division of abnormal cells. The proliferation of cancerous cells is harmful to the human body since it interferes with many biological processes. Lysine-specific demethylase 1(LSD1) protein levels are expressed at high levels in many types of cancers such as teratocarcinoma, embryonic carcinoma, and embryonic stem cells. Gene expression in cancerous cells can be repressed by lysine-methylation on histones which ensures the maintenance of a tightly organized histone. Targeting LSD1 protein levels can significantly impair the growth of cancer due to the methylated histones being unable to participate in gene expression. Lysine-specific demethylase 1(LSD1) inhibitors prevent the proliferation of cancer by targeting the high concentrations of lysine-specific demethylases vital for cell proliferation. CBB3001 is a LSD1 inhibitor which has been able to inhibit the growth of cancer, warranting further investigation. The aim of this research project is to synthesize CBB3001 by developing efficient synthetic methods and to then create a CBB3001 derivatization library. The researchers involved will synthesize CBB3001, a LSD1 inhibitor, by developing several synthetic pathways with variability along specific steps to produce CBB3001 derivatives. CBB3001, and its derivatives, show great promise in functioning as anti-cancer reagents for many types of human cancers.


Nov 15 - 19 2021


All Day


HNSE: Podium Session 3
The Office of Undergraduate Research


The Office of Undergraduate Research


One Reply to “HNSE-O3-5. Development of Novel Synthetic Methods of Lysine-Specific Demethylase 1(LSD1) Inhibitors as Anti-Cancer Reagents”

  1. Hello Citlally and Lilian,
    I found your presentation very interesting and informative. I love looking at presentations I know nothing about because I can learn a lot from them! I can tell by the diagrams and explanation you two have done extensive research. It’s clear you both know what you’re talking about and you can show/explain it while presenting. My only criticism is the lack of background/simple explanations. I felt lost at times because of my lack of knowledge of cancer and chemistry. There was a lot of information and I couldn’t understand it because to me, all the diagrams looked the same. This subject can be complicated so simplifying in some areas could be beneficial for clarity. Overall, I learned a lot from this presentation, and it’s an awesome podium presentation.

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