OREO-2. The Effects of Hypothalamic Stem Cell Degradation on Systemic Aging

Christian Rebolledo1
Faculty Mentor: Levent Atici, Ph.D.2
1Sierra Vista High School
2Division of Research, Office of Undergraduate Research

Many aspects of human biological degradation have been attributed to the continual loss of stem cells throughout the course of an organism’s life. One specific aspect is the underlying disease that is aging. Through the depletion of Sox-2-expressing hypothalamic stem cells (htNSCs), it has been correlated that the decrease of htNSCs results in loss of physiological, and biochemical function in mice specifically. The deductions stated throughout are through the compilation of studies across aspects like htNSC senescence, exosomal neural miRNA production, and protein-associated biological aging. As htNSCs produce exosomal miRNAs including CD81 and lncRNA Hnscr, neural function exhibited in mice has been found to be about 75% less effective in older populations (18 months of age in comparison to 3 months of age) producing fewer miRNA systems. Additionally, the YB-1 protein identified in mice (and humans) has been found to play a key role in the activation of cellular senescence in htNSCs, which through a decrease in specifically the lncRNA Hnscr, results in the compounding effects of systemic aging. These studies suggest that all together, a lack of htNSCs results in a lack of protein and exosomal miRNA systems in mice that aid in maintaining cellular stability. Since mice and humans seem to exhibit similar homology in regards to neural microbiology, it may be possible to reverse the effects of aging in humans through supplemental miRNA and Hnscr systems in vitro, as was done in mice, to further implement these studies in the future.


Nov 15 - 19 2021


All Day


The Office of Undergraduate Research


The Office of Undergraduate Research


3 Replies to “OREO-2. The Effects of Hypothalamic Stem Cell Degradation on Systemic Aging”

  1. This was a very interesting and well done presentation which essentially explained the exact effects of aging, and what exactly causes the degradation in humans as we age due to lack of ntHScs. The idea that we can delay these negative effects through just maintaining a steady level of htNSCs, and prolong the effects of aging in humans. To be able to go into this level depth, and demonstrate great visuals which are able to explain the concept of htNSCs really aided in helping me understand what exactly was being talked about. Overall, great job on this presentation.

  2. Hello all, and welcome to my presentation on the effects stem cells have on systemic aging! In the comment section, please feel free to ask any questions and I will get back to you as soon as possible. Enjoy!

    1. This presentation was very interesting! The effects stem cells have on aging is very intriguing and I think it was explained throughly and in an excellent way! All of the information provided was very key and I felt like all of it was necessary. Awesome presentation thanks for sharing!

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